Bioshock 2 tegevus toimub enne mängu esimese osa tegevust. Seekord astub mängija Big Daddy prototüübi kingadesse ja saab teada, kui tugevad need vennikesed tegelikult on.

Nõuded arvutile:

Miinimum:
• OS: Windows XP, Vista, Windows 7
• Processor: AMD Athlon 64 Processor 3800+ 2.4Ghz or better, Intel Pentium 4 530 3.0Ghz Processor or better
• Memory: 2GB
• Graphics: NVIDIA 7800GT 256MB graphics card or better, ATI Radeon X1900 256MB graphics card or better
• DirectX®: DirectX 9.0c
• Hard Drive: 11GB
• Sound: 100% DirectX 9.0C compliant sound card or onboard sound

Soovituslik:
• Processor: AMD Athlon 64 X2 5200+ Dual Core 2.60Ghz, Intel Core 2 Duo E6420 Dual Core 2.13Ghz
• Memory: 3GB
• Graphics: NVIDIA 8800GT 512MB graphics card or better, ATI Radeon HD4830 512MB graphics card or better

Other Requirements:
Initial installation requires one-time internet connection; Ability to save game, earn achievements, receive title updates and online play requires log-in to Games for Windows LIVE; software installations required including Microsoft Visual C++2008 Runtime Libraries, Games for Windows LIVE client, Games for Windows LIVE Client Patch, Sony DADC SecuROM, Microsoft DirectX.